Novel MHC Class I Structures on Exosomes

Novel MHC class I structures on exosomes.

Exosomes are nanometer-sized vesicles released by a number of cell types including those of the immune system, and often contain numerous immune recognition molecules including MHC molecules. We demonstrate in this study that exosomes can display a significant proportion of their MHC class I (MHC I) content in the form of disulfide-linked MHC I dimers. These MHC I dimers can be detected after r...

MHC class I multimers

T lymphocytes play a key role in the immune response to both foreign and self peptide antigens, which they recognize in combination with MHC molecules. In the past it has been difficult to analyse objectively the specificity, frequency and intensity of T cell responses. The recent application of fluorescent-labelled MHC class I multimers, however, has provided a powerful experimental approach t...

Novel Machine Learning Methods for MHC Class I Binding Prediction

MHC class I molecules are key players in the human immune system. They bind small peptides derived from intracellular proteins and present them on the cell surface for surveillance by the immune system. Prediction of such MHC class I binding peptides is a vital step in the design of peptide-based vaccines and therefore one of the major problems in computational immunology. Thousands of differen...

Complexes to Dendritic Cells Transfer Functional MHC Class I/Peptide Vaccine. I. Dendritic Cell-Derived Exosomes Exosomes as Potent Cell-Free Peptide-Based

Human Papillomavirus and Cancer - Immunological Consequences of MHC Class I Down-Regulation

Few studies have been conducted on the causative factors associated with the development of cancer. Infection by high risk human papillomaviruses (HPVs) have been implicated as causative agents in a variety of cancers. HPV is capable of evading immune system and establishing persistent infections. Prolonged infection and lesion maintenance are associated with higher risk of neoplastic progressi...